Advancing chromatography. Empowering scientists.

I have been using DryLab since my PhD studies and continue to rely on it in my current role at Bayer AG. DryLab allows us to efficiently predict retention behavior and assess the impact of changing compound mixtures, significantly reducing experimental effort during method development. Its strong scientific foundation, based on established chromatographic models, delivers reliable results, while the software continues to evolve with valuable new capabilities. Beyond its practical benefits, DryLab is also an excellent learning tool, backed by a highly responsive and knowledgeable support team.

I've used DryLab for 10 years as an integral part of my approach to HPLC method development in pharmaceutical development, from early-stage drug candidates through late-stage programs. I have found it particularly valuable for challenging separations involving large, structurally complex small molecules with complicated impurity profiles, including methods where as many as 30 individual peaks needed to be separated. DryLab enables me to explore a much larger chromatographic design space than would be practical experimentally and, importantly, to better understand the factors driving selectivity between closely eluting components. For complex impurity profiles, this ability to model and visualize how changes in chromatographic conditions influence the entire separation can be extremely powerful. That capability is valuable throughout the stages of pharmaceutical development from rapidly identifying effective separation conditions for early-stage candidates to developing increasingly robust and well-understood methods as programs advance. DryLab helps me make more informed development decisions, reduce trial-and-error experimentation, and build greater confidence in method robustness. For me, DryLab is a powerful platform for understanding complex separations and supporting scientifically driven method development decisions.

[…] DryLab is your life jacket if you are drowning in the middle of desperate attempts to improve the quality of your chromatographic separation. With just a limited number of scouting experiments, the software allows you to optimize the quality of the separation with high accuracy in retention time prediction. Moreover, the use of the software improves the knowledge of your system, highlighting how the interaction between different factors (e.g., gradient steepness, column temperature, and the chemical composition of the mobile phase) can affect the quality of the separation. The use of DryLab also represented a learning opportunity in the field of chromatography due to a constant and fruitful scientific exchange with members from the Molnár Institute. Overall, DryLab is a must-have tool that boosted the quality and reliability of my scientific results. […]

As a Contract Research Organisation (CRO), Quality Assistance provides regulatory, scientific and technological expertise to large companies and SMEs in the pharmaceutical industry. Customers around the world rely on us when developing and marketing innovative human medicinal products in compliance with European and US regulations — also because we constantly invest in the most sophisticated technology and equipment. DryLab®'s Empower™ and OpenLab automated Design Space Modeling allows us to streamline the development of analytical procedures, both for small molecules and biotherapeutics. Knowing that our methods are optimised in a way that makes them robust for their subsequent use in any QC environment is a key reason why customers turn to us in product developments from discovery to the market place.

As a pharmaceutical service provider for AQbD-based method development and validation, Chromicent has successfully managed to keep ahead of the scientific and regulatory curve. One reason for this is our usage of DryLab® [...] it reduce screening and evaluation time drastically while ruling out any transfer errors by means of automation. More so, DryLab® helps us provide customers and regulators with information necessary to understand complex chromatographic behaviors. In addition, by using DryLab®, we fully comply with what ICH guidelines Q8, Q9, Q10, Q12 and Q14 expect.