Frequently Asked Questions

DryLab® can work with all types of compounds, including small and large molecules.

DryLab® predicts retention times with over 99% accuracy. We have ca. 180 publications documenting DryLab®’s amazing predictive power!

Yes! Running a large number of experiments is time consuming and mistakes made at the instrument can be costly. DryLab® lets beginners do their learning on the computer instead, and provides immediate feedback as they alter experimental conditions. DryLab® also comes with a tutorial guide and built-in examples for self-instruction. We offer special teaching packages for universities — please contact us for more information.

DryLab® works with all chromatographic data systems. It reads the universal import/export format AIA (Analytical Instrument Association), which is available for “Export” as *.cdf files from any integration software.

There are two options: you can upload *.cdf files by exporting your chromatograms from your integration software in AIA format after integration, or you can copy and paste peak tables with peak areas and retention times from Excel into the peak-tracking page.

When building a 3D model you can choose either the tG-T-pH mode or the tG-T-tC mode (tG: time of gradient; T: temperature; tC: ternary composition of eluent B).

• Gradient Time (tG): choose two run times, differing by a factor of three. For example, for a column of 50 × 2.1 mm, 1.7 µm, you can use gradient times of 3 min and 9 min, with a gradient from 5 to 95 %B.
• Temperature (T): choose two values, differing by 30 °C. For example, 30 °C and 60 °C, or 40 °C and 70 °C.
• pH: choose three values, differing by 0.6 between each consecutive value. For example, 2.0; 2.6; 3.2.
• Ternary Composition %B2 in B1 (tC): choose three values — for example, one with 100% acetonitrile, one with a mixture of acetonitrile and methanol (50:50)(V:V), and one with 100% methanol.

All other conditions must be constant across all input runs.

No! Co-eluting peaks during input runs are expected, and DryLab®’s peak tracking tool has a number of useful features for organizing your peak table, including an automatic peak-splitting button.

Yes! You have the option of entering peak-tailing data during the peak tracking process. DryLab® will use this data to give you a realistic prediction of what your separation will look like when you run your DryLab® conditions in the laboratory.

Yes! DryLab® can predict chromatograms under various instrument and column conditions. You can adjust flow rate, dwell volume, extra column volume and column dimensions without needing to run any additional experiments.

Yes! DryLab® has been pioneering the development of analytical QbD in HPLC since 1986. Many of the present requirements such as Method Operable Design Region (MODR), the Edge of Failure, issues of Risk Assessment, Control Strategy, Continual Improvements, etc., can be easily studied in DryLab®. The results are much higher flexibility in your HPLC methods, and faster commercial authorization.

Strange looking resolution maps and grayed-out or extra wide peaks are typically the result of errors in data entry. First, double-check that you’ve correctly entered your column dimensions and instrument data (such as dwell volume, etc.). Then, check that you’ve uploaded your *.cdf files in the correct order and that you’ve entered your data in the mode selection from lowest to highest. If this does not solve your problem, please contact us for further technical support.

If you purchased DryLab® after 2007, you will simply need to install the new driver for your hardware key. Please contact us for instructions.

System software requirements: Windows 2000, Windows XP (Home or Professional), Windows Vista, Windows 7, Windows 8.

• Minimum hardware: Pentium III processor or comparable, 1024 MB RAM, color monitor with 1024×768 display at 16-bit color depth, 45 MB free hard disk space, DryLab® key if required.
• Recommended hardware: 4096 MB RAM, color monitor with 1920×1080 display at 32-bit color depth, 90 MB free hard disk space, DryLab® key if required.

You can purchase DryLab® directly through us at Molnár-Institute. Please contact us by phone (+49 30 421 5590) or by email to request a quotation and/or more information.